Mitochondrial Diseases

Mitochondrial Diseases are very diverse. Specialized organelles in every cell of the body (only red blood cells lack mitochondria). Mitochondria generate more than 90% of the energy required by the body. Mitochondrial dysfunction depletes cells of energy causing cell damage and even cell death. Due to the high energy requirements of brain and muscle, mitochondrial disease typically affect these parts of the body causing Brain and Muscle disease. Other organs are frequently affected including: eye, ears, heart, liver, gastrointestinal tract, liver, kidney, endocrine system, nd blood.The diseases predominantly affect children, but adult-onset disorders are being recognized with increasing frequency. Mitochondria are unique organelles because they are the products of their own genetic material and nuclear DNA. Therefore, mitochondrial diseases are caused by mutations in either mtDNA or nuclear DNA. Mitochondrial diseases are often difficult to diagnose and therefore, it is important for patients to be evaluated at a medical center with appropriate expertise.Physical examination and laboratory tests are necessary to characterize involvement of various organs and to reach the correct diagnosis. Laboratory studies typically include: blood tests, brain MRI or CT scans, heart tests, ophthalmological and neurological evaluations. Finally, genetic testing of blood, urine, or muscle is performed to pinpoint the exact mutation responsible for a specific disease. Treatment of mitochondrial diseases is limited. Therapies to treat specific symptoms and signs of mitochondrial diseases are very important.For example, in mitochondrial patients, epilepsy typically responds to anti-convulsant drugs while insulin and other standard treatments are effective for diabetes mellitus. Retinitis pigmentosa is an inherited mitochondrial condition that involves both eyes. If it starts in one eye,it usually moves to the next eye. There are about 75,000 people in the United States with retini tis pigmentosa (RP). Since retinitis pigmentosa begins as rod degeneration, the patient first notices increasing difficulty in night vision, followed by ifficulty seeing in the periphery.Slowly progressive constriction of the visual field leads to tunnel vision. A small area of central vision in both eyes usually persists for years. Generally night blindness precedes tunnel vision by years or even decades. Total blindness eventually ensues in most cases. For years, vitamin A therapy has been recommended for many RP patients, based on research dating back to the early 1990s. , it has been the only treatment found that slows the RP process. Mitochondrial Diseases By eliJahcolas1

Differences Between Pr and Advertising Essay

Differences Between Advertising and Public Relations Advertising vs. public relations, these two industries are very different even though they’re commonly confused as being one and the same. The following ten properties just scratch the surface of the many differences between advertising and public relations. 1. Paid Vs Free Coverage * Advertising: The company pays for ad space. You know exactly when that ad will air or be published. For Example: Infosys gives an ad in The Hindu on Wednesdays in the Opportunities column. So it has the liberty and control to opt whether they want to give the ad on a particular Wednesday or not depending on their requirement. * Public Relations: Your job is to get free publicity for the company. From news conferences to press releases, you’re focused on getting free media exposure for the company and its products/services. For Example: Tata Nano is the best example of this. Till now Nano was not advertised and all its publicity is through PR. 2. Creative Control Vs. No Control * Advertising: Since you’re paying for the space, you have creative control on what goes into that ad. Any feature of the ad can be designed according to the way you want to portray the image of your company. For Example: Close-up portrays a youthful image through its advertisements, whereas Cadbury (which earlier had largely targeted the youth) has shifted its focus and now projects its chocolate as something for the whole family to enjoy during times of rejoicing. * Public Relations: You have no control over how the media presents (or misrepresents) information about your organization. For Example: Reliance did not have a control over the news which was published regarding the conflict between Mukesh Ambani and Anil Ambani and had to pay for it in form of loss in the share price (initially). 3. Shelf Life * Advertising: Since you pay for the space, you can run your ads over and over for as long as your budget allows. An ad generally has a longer shelf life than one press release. * Public Relations: You generally submit a press release about a new product once. You only submit a press release about a news conference once. The PR exposure you receive is only circulated once. An editor won’t publish your same press release three or four times in their magazine. 4. Wise Consumers * Advertising: Consumers know when they’re reading an advertisement they’re trying to be sold a product or service. The consumer understands that we have paid to present our selling message to him or her, and unfortunately, the consumer often views the selling message very guardedly. * Public Relations: When someone reads a third-party article written about your product or views coverage of your event on TV, they’re seeing something you didn’t pay for and view it differently than they do paid advertising. Where we can generate some sort of third-party ‘endorsement’ by independent media sources, we can create great credibility for our clients’ products or services. 5. Creativity * Advertising: In advertising, you get to exercise your creativity in creating new ad campaigns and materials. Some jingles in the ad have a long bonding with the product. Few Examples: Surf comes with a series of new ads from time to time. Britannia’s jingle is well remembered and is branded even in its website. * Public Relations: In public relations, you have to have a nose for news and be able to generate buzz through that news. You exercise your creativity, to an extent, in the way you search for new news to release to the media. For Example: Apple iPhone is an example of this. Apple created a huge buzz in the market exercising creativity to and extend and the result was a huge demand for the Iphone much before its release date. 6. Target Audience or Hooked Editor * Advertising: You’re looking for your target audience and advertising accordingly. You wouldn’t advertise a women’s TV network in a male-oriented sports magazine. * Public Relations: You must have an angle and hook editors to get them to use info for an article, to run a press release or to cover your event. . 7. Special Events * Advertising: If your company sponsors an event, you wouldn’t want to take out an ad giving yourself a pat on the back for being such a great company. This is where your PR department steps in. Public Relations: If you’re sponsoring an event, you can send out a press release and the media might pick it up. They may publish the information or cover the event. 8. Writing Style * Advertising: Buy this product! Act now! Call today! These are all things you can say in an advertisement. You want to use those buzz words to motivate people to buy your product. * Public Relations: You’re stric tly writing in a no-nonsense news format. Any blatant commercial messages in your communications are disregarded by the media.

Contested masculinities Essay Example | Topics and Well Written Essays - 2000 words

Contested masculinities - Essay Example With reference to Brett Easton Ellis’s American Psycho (1991) and Jackie Kay’s Trumpet (1998), this essay explores the multitude of expressions of masculinity within and between cultures. Contemporary theorists of masculinity have increasingly noted the idea of a post-feminist male identity (Burr 1995). There is a perceived backlash towards advances in feminism over the last quarter century that posits male identity in direct opposition to feminism. In books such as Backlash and Stiffed, Susan Faludi has identified a crisis in masculinity and a resultant wave of males attempting to reassert traditional identity constructions. She discusses ways in which men have lost significance in modern society. Writers such as Benjamin Brabon have discussed the appearance of such expressions of masculinity in cultural artifacts such as the film Falling Down, arguing that the white-male main character is acting out in the film because his previously dominate social position western society has been dislocated in the new millennium (Brabon 57). Other writers identify the normative standards that underline many expressions of male masculinity and explore the resultant backlash (Bark er 2008). These interpretations of ‘post-feminist man’ has incorporated the violent outbursts of males in contemporary society and films as extensions of phallus emasculation experienced as a result of these feminist advances. In fact, statistical research has shown that over the last twenty-year period woman are more than twice as likely to report being attacked by a significant other (Hatty 5). In terms of patriarchy, Thomas Byer argues that: Perhaps the major – function and driving force of patriarchal narrative is the attempt to re-member a masculine body whose member has been â€Å"dissed† Thus sadism and violence directed against women are not in themselves synonymous with narrative; rather they are among the most common, and most virulently misogynist,

Financial Management of eBay Company Assignment

Financial Management of eBay Company - Assignment Example One of the company's strategic business units is Ebay Marketplace-actually the core among its businesses. eBay aims to increase the volume of transactions that are conducted by users as part of its operational objective. By increasing the per-transaction value, as well as its volume, eBay aims to increase its overall objective of increasing operating profit margin. Ebay's human resource policy includes creating a good and friendly environment for its company, where employees will always have an environment which will be human at all times. This includes activities that aim to provide services for employees' convenience including a gym, restaurant, coffee shop and relaxation rooms, as well as family events for special holidays and occasions. Apart from ordinary employees, managers in Ebay are given bonuses and economic benefits as part of their remuneration, as regards the company's human resource policies. By including bonuses and other economic benefits to people who hold top positions in the company, the company aims to improve accountability and lessen the agency costs-with top managers as the agency to the shareholders. Consider the extent to which these objectives are in conflict with each other.On one hand, the company aims to improve its operating profit margin. On the other hand, costs that are related to increasing...eBay aims to increase the volume of transactions that are conducted by users as part of its operational objective. By increasing the per-transaction value, as well as its volume, eBay aims to increase its overall objective of increasing operating profit margin. Ebay's human resource policy includes creating a good and friendly environment for its company, where employees will always have an environment which will be human at all times. This includes activities that aim to provide services for employees' convenience including a gym, restaurant, coffee shop and relaxation rooms, as well as family events for special holidays and occasions.  

Criminal Law-Offences against the person (LLB) Essay

Criminal Law-Offences against the person (LLB) - Essay Example America has enacted specific laws to criminalise the activity of those that spread the disease, whilst the UK relies on existing laws to prefer charges. At present within the UK those deliberately or recklessly infecting others in the manner described above are likely to find themselves charged with offences covered by the Offences Against the Person Act 1861. To date those who have been found guilty have been convicted under s20 of this Act. Under this section the charge preferred is one of recklessly inflicting grievous bodily harm. The cases of R v Konzani1 and R v Dica2 are examples where the courts applied section 2 of the OAPA where the defendants recklessly infected others with HIV. When deliberating on what charges can be brought against those who infect others with HIV the courts will look for proof that the person is aware of their condition that they know the risk of transmission, and they are aware that it passes through sex. People in these circumstances have been found guilty of recklessly inflicting grievous bodily harm. In the case of Dica the court of appeal accepted a submission from the defence that the infected person had consented to the risk of transmission overruling the previous decision of the court where Dica had been found guilty of infecting the injured party. The case of Konzani followed a similar line on consent with the Court of Appeal clarifying how consent should be determined3. In this case, the court of appeal stated that they would only accept that the injured party had consented to the risk, if the defendant can prove that the injured party had been fully informed of their condition, and had made a conscious decision based on that knowledge. Agreeing to unprotected sex could not be viewed as consent to the risk of contracting HIV. The current guidelines on charges that can be brought against

Deception in the investigative, interrogation, and testimonial Essay

Deception in the investigative, interrogation, and testimonial processes - Essay Example The fact is that the law often supports police detection, although police action is limited without an arrest or search warrant. The police conduct detection within a contradictory moral order wherein certain fidelities fuse with certain betrayals (Skotnick). The detection process has three stages and deception can and does occur in any or all of these (Skotnick, 1985). These are investigation, interrogation and testimony. Within the policeman's broad moral cognition, the acceptability of deception depends on the level of criminal process: It is most acceptable to the police and the courts at the investigation stage, less during interrogation and least at the testimonial stage in the courtroom. Increasingly stringent normative constrains account for the differences among the levels and stages. Courtroom testimony is given under oath, whereby witnesses sweat to tell only the truth and nothing but the truth. It is the norm to accept that a witness is telling the truth in court. Courtroom lying violates the basic justice system, which all the parties are assumed to uphold. A policeman who lies in the courtroom can work his way out of his predicament by insisting that judicial interpretations of his limitations can get on the way of his abil ity of performing his job. This appears to be true within the context of the forces, which operate within the investigative stage of an adversary system, wherein the end justifies the means. The policeman seems to have the "privilege" of lying to get to the truth in achieving justice through due process (Skotnick). It may be quaint and a contradiction of values and norms but it is also factual that police freely admit to deceiving suspects and defendants to catch them, yet lying policemen and detectives do not admit to committing perjury (Skotnick, 1985). Perjury is as systematic as police work and police know among themselves that they perjure as a norm rather than as an individual error. A study, conducted by Columbia law students on the effect of Mapp v. Ohio on police practices in New York City, on certain search and seizure cases showed that uniformed police fabricated grounds for arrest in narcotics cases in meeting the requirements of Mapp. This does not justify but only explains how police who falsely witness justify the practice for the sake of greater persuasiveness. They resort to lying as routine of shaking themselves out of a predicament or helping one another out of it and because of a skeptical attitude towards a system, which is disinclined towards the truth that would be favor able to the criminal. The law allows a policeman to lie during the investigative stage but forbids it during the testimonial stage in the courtroom where and when he is certain of the guilt of the suspect, unlike during the investigative stage. The lying policeman puts more value on a short-term objective of suppressing evidence than on the long-term principle of due process in protecting the dignity of the accused. The policeman's pursuit is to legitimize the evidence he presents rather than weigh and analyze its sufficiency. He is merely after complying with the arrest laws, although this compliance often involves manipulation

All About Controlled Drugs Assignment Example | Topics and Well Written Essays - 750 words

All About Controlled Drugs - Assignment Example 4. Intra-spinal: provides direct access to the spinal cord for the administration of specific drugs such as anesthetics. Requires trained staff and damage to the cord or hemorrhage are the disadvantages. (Howland, 2006) 6. Inhalational: main advantage is its use in the administration of anesthetic drugs as well as drugs for respiratory diseases since it provides easy access to lungs. Also, quick action because of extensive blood supply of lungs is another advantage. The short duration of action due to less partial pressure and exhalation of the inspired drug is a major disadvantage. Another disadvantage is a short list drug that can be administered by this route. (Howland, 2006) The major drug interactions and actions in the body include: Durg-Drug interaction i.e. addition of another drug might enhance or lower the activity of the drug. First Pass metabolism i.e. Drugs have taken through oral route undergo a process of activation and metabolism. This decreases their decreases their bioavailability and provides the bloodstream with the active metabolite of the drug. Drug-Enzyme interaction i.e. several enzymes in the body act on drugs to release their active metabolites. Drug-Receptor Interaction i.e. Final action of the drugs takes place when they bind to their specific receptors and cause either activation or deactivation of the receptor to produce the desired effect. (Katzung, 2009) Antidepressants: these drugs include Diazepam, Verapamil and Lorazepam etc. the generic names are Xanax etc. These drugs more commonly known as sleeping pills inhibit Gaba receptor and lower the levels of stress. Opioids: These drugs have a specific action of painkillers. They act on their specific opioid receptors in the body namely alpha, beta, and mu. They bind to these receptors and inhibit the transmission of pain sensation or alteration of brain’s perception of pain. (Howland, 2006)